Please check the table below for supported mail clients.

ApplicationsSupported?Extra Notes
Outlook Web AccessYeshttps://Mail.Office365.com
Outlook 365
(Mac and PC)
Yes
Outlook 2019Yes
Outlook 2016Yes
Outlook 2013NoWill need to upgrade version or use Outlook Web Access (https://Mail.Office365.com)
Pre-Outlook 2013NoWill need to upgrade version or use Outlook Web Access (https://Mail.Office365.com)
Mac Mail on OS 10.13 (High Sierra) or earlierNoNeed to upgrade to a new version of macOS or use Outlook Web Access (https://Mail.Office365.com)
Mac Mail on OS 10.14 (Mojave) or laterYesThere is a bug in Mac Mail that can cause your Office 365 profile to be deleted if the iCloud Keychain is enabled. Until this bug is corrected by apple you may need to disable the iCloud Keychain as a workaround.
Linux Evolution MailYesOr other Linux mail application that support Modern Authentication.
Configuration Information
ThunderbirdNo
EudoraNo
PineNo
Other IMAP4 or POP3No

Smartphone/Tablet/Mobile Device

ApplicationsSupported?Notes
Outlook Web AccessYeshttps://Mail.Office365.com
OutlookYesAvailable in the Apple and Android store
Mail on AndroidNoDownload Outlook for the Android app from the Android store or use Outlook Web Access (https://Mail.Office365.com)
Mail on iOS 11 or laterYesYou may need to delete and re-add your mail profile to get Duo MFA to work.
Mail on iOS 10 or earlierNoUpgrade to iOS 11 or later or use Outlook Web Access (https://Mail.Office365.com)
Chromebooks?We are still testing this. Supported with Outlook Web Access (https://Mail.Office365.com)